Centrilobular necrosis in acute presentation of Japanese patients with type 1 autoimmune hepatitis
نویسندگان
چکیده
منابع مشابه
Circulating microRNA Profiles in Patients with Type-1 Autoimmune Hepatitis
Recent studies have demonstrated that micro (mi)RNA molecules can be detected in the circulation and can serve as potential biomarkers of various diseases. This study used microarray analysis to identify aberrantly expressed circulating miRNAs in patients with type 1 autoimmune hepatitis (AIH) compared with healthy controls. Patients with well-documented and untreated AIH were selected from the...
متن کاملCentrilobular zonal necrosis as a hallmark of a distinctive subtype of autoimmune hepatitis
BACKGROUND AND AIM Centrilobular zonal necrosis (CZN) is a known histological variant of autoimmune hepatitis (AIH). However, the significance of CZN is yet to be fully elucidated. This study aimed to determine whether CZN is a hallmark of a distinctive subtype of AIH. METHODS Histological changes in the centrilobular zones of liver biopsies from 113 AIH patients were assessed by a single pat...
متن کاملAssociation of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population
BACKGROUND/AIMS Recent studies demonstrated an association of STAT4 polymorphisms with autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, indicating multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 polymorphisms on the susceptibility and phenotype of type-1 autoimmune hepatitis in a Japanese Nation...
متن کاملType 1 autoimmune hepatitis presenting with severe autoimmune neutropenia
Autoimmune hepatitis (AIH) is a progressive, chronic liver disease characterized by unresolving hepatocellular inflammation of autoimmune origin. The clinical spectrum may vary from asymptomatic presentation, to non-specific symptoms such as fatigue, arthralgias, nausea and abdominal pain, to acute severe liver disease. AIH is characterized by the presence of interface hepatitis and portal plas...
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ژورنال
عنوان ژورنال: World Journal of Hepatology
سال: 2012
ISSN: 1948-5182
DOI: 10.4254/wjh.v4.i9.262